As a dietary supplement, the effects of NMN (nicotinamide mononucleotide) may vary from person to person.
01 Boosts Energy Metabolism
NAD+ (nicotinamide adenine dinucleotide) is a key coenzyme in intracellular energy metabolism, participating in critical metabolic pathways such as glycolysis and the tricarboxylic acid (TCA) cycle. For men, this helps increase bodily energy levels—especially during physical activity or periods of high work stress—providing better energy support for the body and reducing fatigue.
For instance, some men engaged in physical labor may find that after taking NMN, their endurance during work improves, and they are not as easily fatigued as before.
02 Improves Cardiovascular Health
NMN supports cardiovascular health in multiple ways:
- It enhances the function of vascular endothelial cells and promotes the synthesis of nitric oxide (NO). As an important vasodilator, NO relaxes blood vessels, lowers blood pressure, and reduces the risk of cardiovascular diseases.
- It improves mitochondrial function and reduces oxidative stress damage to cardiac muscle cells.
This is particularly important for men, as they face a relatively higher risk of cardiovascular diseases. Studies suggest that appropriate NMN supplementation may help lower men’s risk of heart attacks and strokes.
03 Enhances Muscle Strength and Endurance
As men age, their muscle mass and strength gradually decline.
NMN activates longevity proteins like SIRT1 (silent information regulator 1), which play a key role in muscle cell metabolism and repair. By activating SIRT1, NMN promotes muscle cells’ uptake of glucose and fatty acids, providing more energy for muscle contraction.
Additionally, it stimulates the proliferation and differentiation of muscle stem cells, helping to increase muscle mass and strength. For example, some fitness enthusiasts notice improved muscle endurance and recovery ability during strength training after taking NMN.
04 Improves Cognitive Function
In men’s brains, NMN helps maintain neuronal health:It increases NAD+ levels to activate neuroprotective signaling pathways, such as the PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) pathway—critical for maintaining mitochondrial function, reducing neuroinflammation, and alleviating oxidative stress.
Men often face high stress in work and life, making them prone to cognitive fatigue and memory decline. By improving brain energy metabolism and neuroprotective mechanisms, NMN may enhance men’s focus, memory, and mental agility—for example, enabling better performance when learning new knowledge or handling complex work tasks.
05 Protects Liver Health
NMN supports liver detoxification and protects liver function:The liver is a vital metabolic organ, and men’s livers are more susceptible to damage due to factors like alcohol consumption and high-fat diets. NMN enhances the detoxification capacity of liver cells, promotes the oxidative breakdown of fatty acids, and reduces fat accumulation in the liver—thus preventing liver diseases such as fatty liver.
It also mitigates liver damage caused by drugs and toxins: by activating the antioxidant enzyme system in liver cells, it scavenges free radicals and preserves the integrity of liver cells.
06 Enhances Sleep Quality
Men often experience sleep issues due to greater stress in social and professional life.
NMN regulates the expression of circadian rhythm-related genes, stabilizing the body’s circadian clock. It acts on the core regulatory mechanism of the circadian clock by influencing the activity of proteins like SIRT1.
A stable circadian clock helps adjust the sleep-wake cycle, making it easier for men to fall asleep and improving sleep depth and quality. For example, some men with insomnia find that after taking NMN for a period, their sleep duration increases and nighttime awakenings decrease.
07 Improves Reproductive Function
NMN may have positive effects on the male reproductive system:
- It increases NAD+ levels in testicular cells, improving sperm quality and motility. NAD+ participates in sperm cell energy metabolism and DNA repair, reducing sperm DNA damage and increasing the proportion of normally shaped sperm.
- It may regulate the endocrine system, balance men’s sex hormone levels, and support normal sexual and reproductive function.
08 Strengthens the Immune System
NMN enhances men’s immune defenses:It activates immune cells such as T cells and NK cells (natural killer cells)—key players in fighting off pathogens like viruses and bacteria.
By increasing NAD+ levels, NMN promotes the proliferation and functional activity of immune cells, making the immune system more responsive to recognizing and eliminating pathogens. During flu season or when exposed to infectious diseases, men taking NMN may have stronger resistance.
09 Delays Skin Aging
Men’s skin also shows signs of aging with age.
NMN activates genes related to collagen synthesis in skin cells, promoting collagen production—collagen is a key component in maintaining skin elasticity and firmness.
Additionally, it reduces oxidative stress damage in skin cells, inhibits melanin production, and improves skin tone and texture. This helps men maintain a youthful, healthy skin appearance, reducing the appearance of wrinkles and age spots.
10 Extends Healthspan
Combining all the above benefits, NMN may help extend men’s healthspan.
By improving the function of various bodily organ systems—from energy metabolism and cardiovascular health to cognitive function and the immune system—NMN reduces men’s risk of chronic diseases. This allows men to maintain good physical and mental conditions even in old age, enjoying a higher quality of life.