NMN: 4 Key Benefits for Insomnia Sufferers

For those plagued by sleep disorders, NMN is undoubtedly a nutritional supplement worth trying. However, it’s important to note that individual physical conditions and reactions vary.

The body’s circadian rhythm is crucial for regulating the sleep-wake cycle. NMN can regulate the expression of circadian clock genes, making the rhythm more regular and stable.

Studies have found that NMN affects the expression levels of core circadian genes such as Per1 and Per2, aligning their expression rhythms with the normal physiological cycle. This helps adjust the sleep cycle, making bedtime and wake-up time more consistent.

For example, for people with circadian rhythm disruption due to shift work or cross-timezone travel, NMN supplementation may help them adapt to new time rhythms faster and improve sleep quality.

Impaired cellular energy metabolism can affect nervous system function, leading to sleep disorders. As a precursor of NAD+ (nicotinamide adenine dinucleotide), NMN boosts intracellular NAD+ levels, promotes cellular energy metabolism, and provides sufficient energy for nerve cells.

This helps maintain the normal function of the nervous system, stabilizing the secretion and transmission of neurotransmitters to improve sleep.

For instance, for those experiencing sleep issues due to reduced cellular energy caused by aging or chronic diseases, NMN can enhance cellular vitality and alleviate insomnia related to abnormal nervous system function.

Oxidative stress and inflammation are closely linked to sleep quality—excessive oxidative products and inflammatory factors can disrupt sleep. NMN has antioxidant properties, reducing the production of reactive oxygen species (ROS) in cells and lowering oxidative stress levels. It may also regulate inflammation-related signaling pathways to mitigate inflammatory responses.

When the body’s oxidative stress and inflammatory status improve, the internal environment becomes more stable, leading to better sleep quality. It helps people fall into deep sleep more easily and reduces nighttime awakenings.

Neurotransmitters such as serotonin and gamma-aminobutyric acid (GABA) play key roles in regulating sleep. NMN may indirectly regulate the synthesis, release, and metabolism of neurotransmitters by influencing cellular metabolism and signaling pathways.

For example, it may promote serotonin synthesis—serotonin can be further converted into melatonin, a critical hormone for regulating sleep that helps the body fall asleep and maintain sleep.

Additionally, NMN may increase GABA levels. As an inhibitory neurotransmitter, GABA suppresses neural activity, inducing relaxation and sedation to improve sleep.